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KMID : 0351619670080020189
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Kyungpook Medical Journal
1967 Volume.8 No. 2 p.189 ~ p.201
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Blood Volume in the Hypothermic Dog
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Abstract
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Silty-five dogs were cooled to 24-26 C of esophageal temperature by body surface cooling technics with ice water and rewarmed with hot water (46-48C). Dogs were divi ;,~1 into three groups:
Group 1 (30 dogs), in which simple cooling and rewarming were carried out, group 2 (20 dogs), in which total circulatory occlusion was added and group 3 (15 dogs), in which splenectomy was performed prior to cooling.
Hematocrit, red cell volume, plasma volume and circulating blood volume were measured. Plasma volume was measured by using RISA. P.lso arterial blood pressure, venous pressure, and cardiac output by Fick principle were deter-mined.
Results were as follows:
1. Hematocrit was not altered during cooling but increased during rewarming in group 1. It was increased in the period of cooling and re-warming in group 2, however in group 3, it was decreased after splen2ctomy, cooling and rewarming.
2. Red cell volume was not changed significantly in group 1, while it was decreased during rewarming is group 2. In group 3, it decreased after splenectomy, cooling and re~varming.
3. Plasma volume was decreased mean value of 13.3% at 25C of body temperature and 10. 4% during rewarming in Jroup 1. It was markedly decreased after circulatory release and during rewarming (33.6%) in group 2. In group 3, decrease of plasma volume was less pronounced than group 2.
4. Circulating blood volume was decreased mean value of 9.8 % in group 1, but decrease of 11. 6% and 30.4% were noted during cooling and rewarming respectively in group 2. In group 3, it decreased up to 32.4% in the cooling period.
5. In all groups, decrease of arterial blood pressure and cardiac output was greater than that of circulating blood volume. No significant changes in venous pressure were found.
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